Commerce led means that the store system is in the foreground: The frontend maps the structure and content from the web shop such as site structure, navigation, header or footer. Supplementary content flows in from the CMS.
In the content-led approach, on the other hand, the CMS is the technical leader, so the front end reflects the website structure, navigation, header, footer, etc. of the CMS. Supplementary product-relevant information comes from the store system.
Commerce-led integration is currently the most widely used variant. It is particularly suitable if the store is to provide structured detail and overview pages per se in order to present articles comprehensively: with images, descriptions, prices, sizes, configuration options and the like.